GTX71521
Frizzled 6 antibody
Eine Lieferung in diese Region ist nicht möglich.
- SKU:
- GTX71521
- Zusätzliche Namen:
- frizzled class receptor 6 , FZ6 , FZD6 , HFZ6 , NDNC10 , Frizzled 6
- Anwendung:
- IHC-P
- Konzentration:
- 1 mg/ml
- Physischer Zustand:
- Liquid
- Spezies-Reaktivität:
- Human
- Aufreinigung:
- Affinity Purified
- Lagerbedingungen:
- -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
- Hersteller:
- Genetex
- Host:
- Rabbit
- Reaktivitäten:
- Human
- Buffer:
- PBS, 0.1% Sodium azide.
- Immunogen:
- Synthetic 17 amino acid peptide from N-terminal extracellular domain of human Frizzled-6.
- Uniprot:
- O60353
- Synonyme:
- frizzled 6, seven transmembrane spanning receptor;frizzled family receptor 6;frizzled homolog 6;frizzled-6;FZ-6;FZ6;HFZ6;NDNC1;NDNC10;seven transmembrane helix receptor
- Weitere Details:
- This gene represents a member of the 'frizzled' gene family, which encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The protein encoded by this family member contains a signal peptide, a cysteine-rich domain in the N-terminal extracellular region, and seven transmembrane domains, but unlike other family members, this protein does not contain a C-terminal PDZ domain-binding motif. This protein functions as a negative regulator of the canonical Wnt/beta-catenin signaling cascade, thereby inhibiting the processes that trigger oncogenic transformation, cell proliferation, and inhibition of apoptosis. Alternative splicing results in multiple transcript variants, some of which do not encode a protein with a predicted signal peptide.[provided by RefSeq, Aug 2011]
- Versandbedingungen:
- Blue Ice