Chk1 antibody [6F5]

Eine Lieferung in diese Region ist nicht möglich.

SKU:: GTX70303
Zusätzliche Namen:: checkpoint kinase 1 , CHK1
Anwendung:: WB, IF, ICC
Konzentration:: 1 mg/ml
Physischer Zustand:: Liquid
Spezies-Reaktivität:: Human
Aufreinigung:: Protein G Purified
Lagerbedingungen:: -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
Hersteller:: Genetex
Host:: Mouse
Reaktivitäten:: Human
Buffer:: PBS, 20% Glycerol, no preservatives.
Immunogen:: Full-length human Chk1
Klon:: 6F5
Uniprot:: O14757
Synonyme:: cell cycle checkpoint kinase;Checkpoint kinase-1;Checkpoint, S. pombe, homolog of, 1;CHK1;CHK1 checkpoint homolog;Chk1-S;serine/threonine-protein kinase Chk1
Weitere Details:: The protein encoded by this gene belongs to the Ser/Thr protein kinase family. It is required for checkpoint mediated cell cycle arrest in response to DNA damage or the presence of unreplicated DNA. This protein acts to integrate signals from ATM and ATR, two cell cycle proteins involved in DNA damage responses, that also associate with chromatin in meiotic prophase I. Phosphorylation of CDC25A protein phosphatase by this protein is required for cells to delay cell cycle progression in response to double-strand DNA breaks. Several alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Oct 2011]