FEN1 antibody [4E7]

Eine Lieferung in diese Region ist nicht möglich.

SKU:: GTX70185
Zusätzliche Namen:: flap structure-specific endonuclease 1 , FEN-1 , MF1 , RAD2
Anwendung:: ChIP, WB, IF, ICC, IP
Konzentration:: 1.73 mg/ml
Physischer Zustand:: Liquid
Spezies-Reaktivität:: Human
Aufreinigung:: Protein G Purified
Lagerbedingungen:: -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
Hersteller:: Genetex
Host:: Mouse
Reaktivitäten:: Human, Mouse
Buffer:: PBS, no preservatives.
Immunogen:: Recombinant human FEN-1 protein encoding amino acids 1-380 purified E. coli.
Klon:: 4E7
Uniprot:: P39748
Synonyme:: DNase IV;FEN-1;flap endonuclease 1;Flap structure-specific endonuclease 1;Maturation factor 1;maturation factor-1;MF1;RAD2
Weitere Details:: The protein encoded by this gene removes 5' overhanging flaps in DNA repair and processes the 5' ends of Okazaki fragments in lagging strand DNA synthesis. Direct physical interaction between this protein and AP endonuclease 1 during long-patch base excision repair provides coordinated loading of the proteins onto the substrate, thus passing the substrate from one enzyme to another. The protein is a member of the XPG/RAD2 endonuclease family and is one of ten proteins essential for cell-free DNA replication. DNA secondary structure can inhibit flap processing at certain trinucleotide repeats in a length-dependent manner by concealing the 5' end of the flap that is necessary for both binding and cleavage by the protein encoded by this gene. Therefore, secondary structure can deter the protective function of this protein, leading to site-specific trinucleotide expansions. [provided by RefSeq, Jul 2008]

Versandbedingungen:: Blue Ice