GTX70169
UBE3A antibody
Eine Lieferung in diese Region ist nicht möglich.
- SKU:
- GTX70169
- Zusätzliche Namen:
- ubiquitin protein ligase E3A , ANCR , AS , E6-AP , EPVE6AP , HPVE6A
- Anwendung:
- IHC, WB
- Physischer Zustand:
- Liquid
- Spezies-Reaktivität:
- Human
- Aufreinigung:
- Crude Serum
- Lagerbedingungen:
- -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
- Hersteller:
- Genetex
- Host:
- Rabbit
- Reaktivitäten:
- Human
- Buffer:
- Unpurified Serum, no preservatives.
- Immunogen:
- Recombinant protein encoding amino acids residues 1-851 of human UBE3A expressed in E. coli.
- Uniprot:
- Q05086
- Synonyme:
- ANCR;AS;CTCL tumor antigen se37-2;E6-AP;E6AP ubiquitin-protein ligase;EPVE6AP;HECT-type ubiquitin transferase E3A;HPVE6A;human papilloma virus E6-associated protein;human papillomavirus E6-associated protein;oncogenic protein-associated protein E6-AP;renal carcinoma antigen NY-REN-54;ubiquitin-protein ligase E3A
- Weitere Details:
- This gene encodes an E3 ubiquitin-protein ligase, part of the ubiquitin protein degradation system. This imprinted gene is maternally expressed in brain and biallelically expressed in other tissues. Maternally inherited deletion of this gene causes Angelman Syndrome, characterized by severe motor and intellectual retardation, ataxia, hypotonia, epilepsy, absence of speech, and characteristic facies. The protein also interacts with the E6 protein of human papillomavirus types 16 and 18, resulting in ubiquitination and proteolysis of tumor protein p53. Alternative splicing of this gene results in three transcript variants encoding three isoforms with different N-termini. Additional transcript variants have been described, but their full length nature has not been determined. [provided by RefSeq, Jul 2008]
- Versandbedingungen:
- Blue Ice