GTX66231
NUDT15 antibody
Eine Lieferung in diese Region ist nicht möglich.
- SKU:
- GTX66231
- Zusätzliche Namen:
- nudix hydrolase 15 , MTH2 , NUDT15D
- Anwendung:
- WB
- Physischer Zustand:
- Liquid
- Spezies-Reaktivität:
- Human, Rat
- Aufreinigung:
- Affinity Purified
- Lagerbedingungen:
- -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
- Hersteller:
- Genetex
- Host:
- Rabbit
- Reaktivitäten:
- Rat
- Buffer:
- PBS, 50% Glycerol, 0.02% Sodium azide.
- Immunogen:
- Recombinant funsion protein containing a sequence corresponding to amino acids 1-164 of human NUDT15 (NP_060753.1).
- Uniprot:
- Q9NV35
- Synonyme:
- 8-oxo-dGTPase NUDT15;MTH2;mutT homolog 2;Nucleoside diphosphate-linked moiety X motif 15;nucleoside diphosphate-linked to another moiety X hydrolase 15;nucleotide triphosphate diphosphatase NUDT15;nudix (nucleoside diphosphate linked moiety X)-type motif 15;NUDT15D;probable 7,8-dihydro-8-oxoguanine triphosphatase NUDT15;probable 8-oxo-dGTP diphosphatase NUDT15
- Weitere Details:
- This gene encodes an enzyme that belongs to the Nudix hydrolase superfamily. Members of this superfamily catalyze the hydrolysis of nucleoside diphosphates, including substrates like 8-oxo-dGTP, which are a result of oxidative damage, and can induce base mispairing during DNA replication, causing transversions. The encoded enzyme is a negative regulator of thiopurine activation and toxicity. Mutations in this gene result in poor metabolism of thiopurines, and are associated with thiopurine-induced early leukopenia. Multiple pseudogenes of this gene have been identified. [provided by RefSeq, Apr 2016]
- Versandbedingungen:
- Blue Ice