GTX64917
PLOD2 antibody
Eine Lieferung in diese Region ist nicht möglich.
- SKU:
- GTX64917
- Zusätzliche Namen:
- procollagen-lysine,2-oxoglutarate 5-dioxygenase 2 , BRKS2 , LH2 , TLH
- Anwendung:
- WB
- Physischer Zustand:
- Liquid
- Spezies-Reaktivität:
- Human
- Aufreinigung:
- Affinity Purified
- Lagerbedingungen:
- -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
- Hersteller:
- Genetex
- Host:
- Rabbit
- Reaktivitäten:
- Human, Rat
- Buffer:
- PBS, 50% Glycerol, 0.02% Sodium azide.
- Immunogen:
- Recombinant fusion protein containing a sequence corresponding to amino acids 470-650 of human PLOD2 (NP_891988.1).
- Uniprot:
- O00469
- Synonyme:
- BRKS2;LH2;lysine hydroxylase 2;lysyl hydroxlase 2;lysyl hydroxylase 2;procollagen-lysine 5-dioxygenase;procollagen-lysine,2-oxoglutarate 5-dioxygenase 2;telopeptide lysyl hydroxylase;TLH
- Weitere Details:
- The protein encoded by this gene is a membrane-bound homodimeric enzyme that is localized to the cisternae of the rough endoplasmic reticulum. The enzyme (cofactors iron and ascorbate) catalyzes the hydroxylation of lysyl residues in collagen-like peptides. The resultant hydroxylysyl groups are attachment sites for carbohydrates in collagen and thus are critical for the stability of intermolecular crosslinks. Some patients with Ehlers-Danlos syndrome type VIB have deficiencies in lysyl hydroxylase activity. Mutations in the coding region of this gene are associated with Bruck syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
- Versandbedingungen:
- Blue Ice