GTX64637
RASGRP1 antibody
Eine Lieferung in diese Region ist nicht möglich.
- SKU:
- GTX64637
- Zusätzliche Namen:
- RAS guanyl releasing protein 1 , CALDAG-GEFI , CALDAG-GEFII , RASGRP
- Anwendung:
- WB
- Physischer Zustand:
- Liquid
- Spezies-Reaktivität:
- Human
- Aufreinigung:
- Affinity Purified
- Lagerbedingungen:
- -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
- Hersteller:
- Genetex
- Host:
- Rabbit
- Reaktivitäten:
- Human
- Buffer:
- PBS, 50% Glycerol, 0.02% Sodium azide.
- Immunogen:
- Recombinant fusion protein containing a sequence corresponding to amino acids 598-797 of human RASGRP1 (NP_005730.2).
- Uniprot:
- O95267
- Synonyme:
- calcium and DAG-regulated guanine nucleotide exchange factor II;calcium- and diacylglycerol-regulated guanine nucleotide exchange factor II;CALDAG-GEFI;CALDAG-GEFII;guanine nucleotide exchange factor, calcium- and DAG-regulated, Rap1A;IMD64;ras activator RasGRP;RAS guanyl nucleotide-releasing protein 1;RAS guanyl releasing protein 1 (calcium and DAG-regulated);Ras guanyl-releasing protein;RAS guanyl-releasing protein 1;RASGRP
- Weitere Details:
- This gene is a member of a family of genes characterized by the presence of a Ras superfamily guanine nucleotide exchange factor (GEF) domain. It functions as a diacylglycerol (DAG)-regulated nucleotide exchange factor specifically activating Ras through the exchange of bound GDP for GTP. It activates the Erk/MAP kinase cascade and regulates T-cells and B-cells development, homeostasis and differentiation. Alternatively spliced transcript variants encoding different isoforms have been identified. Altered expression of the different isoforms of this protein may be a cause of susceptibility to systemic lupus erythematosus (SLE). [provided by RefSeq, Jul 2008]
- Versandbedingungen:
- Blue Ice