GTX645952
IRE1 alpha (phospho Ser724) antibody [HL5384]
Eine Lieferung in diese Region ist nicht möglich.
- SKU:
- GTX645952
- Zusätzliche Namen:
- endoplasmic reticulum to nucleus signaling 1 , IRE1 , IRE1P , IRE1a , hIRE1p
- Anwendung:
- WB
- Konzentration:
- 1 mg/ml
- Physischer Zustand:
- Liquid
- Spezies-Reaktivität:
- Human
- Aufreinigung:
- Protein A Purified
- Lagerbedingungen:
- 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
- Hersteller:
- Genetex
- Host:
- Rabbit
- Reaktivitäten:
- Human, Mouse
- Buffer:
- PBS, no preservatives.
- Immunogen:
- Carrier-protein conjugated synthetic peptide surrounding phospho Ser724 of human IRE1 alpha. The exact sequence is proprietary.
- Klon:
- HL5384
- Uniprot:
- O75460
- Synonyme:
- Endoplasmic reticulum-to-nucleus signaling 1;ER to nucleus signalling 1;hIRE1p;inositol-requiring 1;inositol-requiring enzyme 1;inositol-requiring protein 1;IRE1;ire1-alpha;IRE1a;IRE1P;protein kinase/endoribonuclease;serine/threonine-protein kinase/endoribonuclease IRE1
- Weitere Details:
- This gene encodes the transmembrane protein kinase inositol-requiring enzyme 1. The encoded protein contains two functional catalytic domains, a serine/threonine-protein kinase domain and an endoribonuclease domain. This protein functions as a sensor of unfolded proteins in the endoplasmic reticulum (ER) and triggers an intracellular signaling pathway termed the unfolded protein response (UPR). The UPR is an ER stress response that is conserved from yeast to mammals and activates genes involved in degrading misfolded proteins, regulating protein synthesis and activating molecular chaperones. This protein specifically mediates the splicing and activation of the stress response transcription factor X-box binding protein 1. [provided by RefSeq, Aug 2017]
- Versandbedingungen:
- Blue Ice