GTX645422
MDM2 antibody [HL5170]
Eine Lieferung in diese Region ist nicht möglich.
- SKU:
- GTX645422
- Zusätzliche Namen:
- MDM2 proto-oncogene , ACTFS , HDMX , hdm2
- Konzentration:
- 1 mg/ml
- Physischer Zustand:
- Liquid
- Spezies-Reaktivität:
- Human
- Aufreinigung:
- Protein A Purified
- Lagerbedingungen:
- 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
- Hersteller:
- Genetex
- Host:
- Rabbit
- Buffer:
- PBS, no preservatives.
- Immunogen:
- Recombinant fragment of human MDM2.
- Klon:
- HL5170
- Uniprot:
- Q00987
- Synonyme:
- ACTFS;Double minute 2 protein;double minute 2, human homolog of; p53-binding protein;E3 ubiquitin-protein ligase Mdm2;hdm2;HDMX;LSKB;MDM2 oncogene, E3 ubiquitin protein ligase;MDM2 proto-oncogene, E3 ubiquitin protein ligase;Mdm2, p53 E3 ubiquitin protein ligase homolog;Mdm2, transformed 3T3 cell double minute 2, p53 binding protein;oncoprotein Mdm2;p53-binding protein Mdm2;RING-type E3 ubiquitin transferase Mdm2
- Weitere Details:
- This gene encodes a nuclear-localized E3 ubiquitin ligase. The encoded protein can promote tumor formation by targeting tumor suppressor proteins, such as p53, for proteasomal degradation. This gene is itself transcriptionally-regulated by p53. Overexpression or amplification of this locus is detected in a variety of different cancers. There is a pseudogene for this gene on chromosome 2. Alternative splicing results in a multitude of transcript variants, many of which may be expressed only in tumor cells. [provided by RefSeq, Jun 2013]
- Versandbedingungen:
- Blue Ice