GTX64408
Perforin antibody
Eine Lieferung in diese Region ist nicht möglich.
- SKU:
- GTX64408
- Zusätzliche Namen:
- perforin 1 , HPLH2 , P1 , PFP
- Anwendung:
- WB, IHC-P, IF, ICC
- Physischer Zustand:
- Liquid
- Spezies-Reaktivität:
- Human, Mouse
- Aufreinigung:
- Affinity Purified
- Lagerbedingungen:
- -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
- Hersteller:
- Genetex
- Host:
- Rabbit
- Reaktivitäten:
- Mouse, Rat
- Buffer:
- PBS, 50% Glycerol, 0.02% Sodium azide.
- Immunogen:
- Recombinant fusion protein containing a sequence corresponding to amino acids 280-555 of human PRF1 (NP_001076585.1).
- Uniprot:
- P14222
- Synonyme:
- cytolysin;HPLH2;lymphocyte pore-forming protein;P1;perforin 1 (pore forming protein);perforin-1;PFP
- Weitere Details:
- This gene encodes a protein with structural similarities to complement component C9 that is important in immunity. This protein forms membrane pores that allow the release of granzymes and subsequent cytolysis of target cells. Whether pore formation occurs in the plasma membrane of target cells or in an endosomal membrane inside target cells is subject to debate. Mutations in this gene are associated with a variety of human disease including diabetes, multiple sclerosis, lymphomas, autoimmune lymphoproliferative syndrome (ALPS), aplastic anemia, and familial hemophagocytic lymphohistiocytosis type 2 (FHL2), a rare and lethal autosomal recessive disorder of early childhood. [provided by RefSeq, Aug 2017]
- Versandbedingungen:
- Blue Ice