SYNGAP1 antibody [HL2292]

Eine Lieferung in diese Region ist nicht möglich.

SKU:: GTX638347
Zusätzliche Namen:: synaptic Ras GTPase activating protein 1 , MRD5 , RASA1 , RASA5 , SYNGAP
Anwendung:: WB, IF, ICC
Konzentration:: 1 mg/ml
Physischer Zustand:: Liquid
Spezies-Reaktivität:: Human, Mouse
Aufreinigung:: Protein A Purified
Lagerbedingungen:: -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
Hersteller:: Genetex
Host:: Rabbit
Reaktivitäten:: Mouse, Rat
Buffer:: PBS, no preservatives.
Immunogen:: Recombinant fragmemt of human SYNGAP1
Klon:: HL2292
Uniprot:: Q96PV0
Synonyme:: MRD5;neuronal RasGAP;Ras GTPase-activating protein SynGAP;ras/Rap GTPase-activating protein SynGAP;RASA1;RASA5;synaptic Ras GTPase activating protein 1 homolog;synaptic Ras GTPase activating protein, 135kDa;Synaptic Ras GTPase-activating protein 1;SYNGAP
Weitere Details:: This gene encodes a Ras GTPase activating protein that is a member of the N-methyl-D-aspartate receptor complex. The N-terminal domain of the protein contains a Ras-GAP domain, a pleckstrin homology domain, and a C2 domain that may be involved in binding of calcium and phospholipids. The C-terminal domain consists of a ten histidine repeat region, serine and tyrosine phosphorylation sites, and a T/SXV motif required for postsynaptic scaffold protein interaction. The encoded protein negatively regulates Ras, Rap and alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor trafficking to the postsynaptic membrane to regulate synaptic plasticity and neuronal homeostasis. Allelic variants of this gene are associated with intellectual disability and autism spectrum disorder. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2016]

Versandbedingungen:: Blue Ice