GPS2 antibody [HL2276]

Eine Lieferung in diese Region ist nicht möglich.

SKU:: GTX638329
Zusätzliche Namen:: G protein pathway suppressor 2 , AMF-1
Anwendung:: WB, IHC-P, IF, ICC
Konzentration:: 2 mg/ml
Physischer Zustand:: Liquid
Spezies-Reaktivität:: Human
Aufreinigung:: Protein A Purified
Lagerbedingungen:: -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
Hersteller:: Genetex
Host:: Rabbit
Reaktivitäten:: Fish, Human, Mouse, Rat
Buffer:: PBS, no preservatives.
Immunogen:: Recombinant fragmemt of human GPS2.
Klon:: HL2276
Uniprot:: Q13227
Synonyme:: AMF-1;G protein pathway suppressor 2;GPS-2
Weitere Details:: This gene encodes a protein involved in G protein-mitogen-activated protein kinase (MAPK) signaling cascades. When overexpressed in mammalian cells, this gene could potently suppress a RAS- and MAPK-mediated signal and interfere with JNK activity, suggesting that the function of this gene may be signal repression. The encoded protein is an integral subunit of the NCOR1-HDAC3 (nuclear receptor corepressor 1-histone deacetylase 3) complex, and it was shown that the complex inhibits JNK activation through this subunit and thus could potentially provide an alternative mechanism for hormone-mediated antagonism of AP1 (activator protein 1) function. [provided by RefSeq, Jul 2008]