![eIF3H / EIF3S3 antibody [GT2712]](https://www.genetex.com/upload/website/prouct_img/normal/GTX633630/GTX633630_42583_20160922_WB_w_23061202_982.webp)
GTX633630
eIF3H / EIF3S3 antibody [GT2712]
Eine Lieferung in diese Region ist nicht möglich.
- SKU:
- GTX633630
- Zusätzliche Namen:
- eukaryotic translation initiation factor 3 subunit H , EIF3S3 , eIF3-gamma , eIF3-p40
- Anwendung:
- WB
- Konzentration:
- 1 mg/ml
- Physischer Zustand:
- Liquid
- Spezies-Reaktivität:
- Human
- Aufreinigung:
- Protein G Purified
- Lagerbedingungen:
- -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
- Hersteller:
- Genetex
- Host:
- Mouse
- Reaktivitäten:
- Human
- Buffer:
- PBS, no preservatives.
- Immunogen:
- Recombinant protein encompassing a sequence within the center region of human eIF3H / EIF3S3. The exact sequence is proprietary.
- Klon:
- GT2712
- Uniprot:
- O15372
- Synonyme:
- eIF-3-gamma;eIF3 p40 subunit;eIF3-gamma;eIF3-p40;EIF3S3;eukaryotic translation initiation factor 3 subunit 3;eukaryotic translation initiation factor 3 subunit H;eukaryotic translation initiation factor 3, subunit 2 (beta, 36kD);eukaryotic translation initiation factor 3, subunit 3 (gamma, 40kD);eukaryotic translation initiation factor 3, subunit 3 gamma, 40kDa
- Weitere Details:
- Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773).
- Versandbedingungen:
- Blue Ice