ALDH2 antibody [4G6A3]

Eine Lieferung in diese Region ist nicht möglich.

SKU:: GTX60727
Zusätzliche Namen:: aldehyde dehydrogenase 2 family member , ALDH-E2 , ALDHI , ALDM
Anwendung:: ELISA, Flow Cytometry, WB, IHC-P, IF, ICC
Konzentration:: 1 mg/ml
Physischer Zustand:: Liquid
Spezies-Reaktivität:: Human
Aufreinigung:: Protein G Purified
Lagerbedingungen:: -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
Hersteller:: Genetex
Host:: Mouse
Reaktivitäten:: Human, Mouse, Rat
Buffer:: PBS, 0.05% Sodium azide.
Immunogen:: Purified recombinant fragment of human ALDH2 (AA: 317-517) expressed in E. Coli.
Klon:: 4G6A3
Uniprot:: P05091
Synonyme:: acetaldehyde dehydrogenase 2;aldehyde dehydrogenase 2 family (mitochondrial);aldehyde dehydrogenase, mitochondrial;ALDH class 2;ALDH-E2;ALDHI;ALDM;epididymis secretory sperm binding protein;liver mitochondrial ALDH;nucleus-encoded mitochondrial aldehyde dehydrogenase 2
Weitere Details:: This protein belongs to the aldehyde dehydrogenase family of proteins. Aldehyde dehydrogenase is the second enzyme of the major oxidative pathway of alcohol metabolism. Two major liver isoforms of aldehyde dehydrogenase, cytosolic and mitochondrial, can be distinguished by their electrophoretic mobilities, kinetic properties, and subcellular localizations. Most Caucasians have two major isozymes, while approximately 50% of Orientals have the cytosolic isozyme but not the mitochondrial isozyme. A remarkably higher frequency of acute alcohol intoxication among Orientals than among Caucasians could be related to the absence of a catalytically active form of the mitochondrial isozyme. The increased exposure to acetaldehyde in individuals with the catalytically inactive form may also confer greater susceptibility to many types of cancer. This gene encodes a mitochondrial isoform, which has a low Km for acetaldehydes, and is localized in mitochondrial matrix. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Mar 2011]

Versandbedingungen:: Blue Ice