VAV1 antibody [2E11]

Eine Lieferung in diese Region ist nicht möglich.

SKU:: GTX60621
Zusätzliche Namen:: vav guanine nucleotide exchange factor 1 , VAV
Anwendung:: ELISA, Flow Cytometry, WB
Konzentration:: 1 mg/ml
Physischer Zustand:: Liquid
Spezies-Reaktivität:: Human
Aufreinigung:: Protein G Purified
Lagerbedingungen:: -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
Hersteller:: Genetex
Host:: Mouse
Reaktivitäten:: Human
Buffer:: PBS, 0.05% Sodium azide.
Immunogen:: Purified recombinant fragment of human VAV1 (AA: 121-324) expressed in E. Coli.
Klon:: 2E11
Uniprot:: P15498
Synonyme:: proto-oncogene vav;VAV;vav 1 guanine nucleotide exchange factor;vav 1 oncogene
Weitere Details:: This gene is a member of the VAV gene family. The VAV proteins are guanine nucleotide exchange factors (GEFs) for Rho family GTPases that activate pathways leading to actin cytoskeletal rearrangements and transcriptional alterations. The encoded protein is important in hematopoiesis, playing a role in T-cell and B-cell development and activation. The encoded protein has been identified as the specific binding partner of Nef proteins from HIV-1. Coexpression and binding of these partners initiates profound morphological changes, cytoskeletal rearrangements and the JNK/SAPK signaling cascade, leading to increased levels of viral transcription and replication. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Apr 2012]

Versandbedingungen:: Blue Ice