Doublecortin antibody [2G5]

Eine Lieferung in diese Region ist nicht möglich.

SKU:: GTX60612
Zusätzliche Namen:: doublecortin , DBCN , DC , LISX , SCLH , XLIS
Anwendung:: ELISA, Flow Cytometry, WB, IHC-P, IF, ICC
Konzentration:: 1 mg/ml
Physischer Zustand:: Liquid
Spezies-Reaktivität:: Human
Aufreinigung:: Protein G Purified
Lagerbedingungen:: -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
Hersteller:: Genetex
Host:: Mouse
Reaktivitäten:: Human, Mouse
Buffer:: PBS, 0.05% Sodium azide.
Immunogen:: Purified recombinant fragment of human Doublecortin (AA: 362-411) expressed in E. Coli.
Klon:: 2G5
Uniprot:: O43602
Synonyme:: DBCN;DC;doublecortex;doublin;lis-X;lissencephalin-X;LISX;neuronal migration protein doublecortin;SCLH;XLIS
Weitere Details:: This gene encodes a member of the doublecortin family. The protein encoded by this gene is a cytoplasmic protein and contains two doublecortin domains, which bind microtubules. In the developing cortex, cortical neurons must migrate over long distances to reach the site of their final differentiation. The encoded protein appears to direct neuronal migration by regulating the organization and stability of microtubules. In addition, the encoded protein interacts with LIS1, the regulatory gamma subunit of platelet activating factor acetylhydrolase, and this interaction is important to proper microtubule function in the developing cortex. Mutations in this gene cause abnormal migration of neurons during development and disrupt the layering of the cortex, leading to epilepsy, mental retardation, subcortical band heterotopia ("double cortex" syndrome) in females and lissencephaly ("smooth brain" syndrome) in males. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2010]

Versandbedingungen:: Blue Ice