GTX60332
ETO / RUNX1T1 antibody - ChIP grade
Eine Lieferung in diese Region ist nicht möglich.
- SKU:
- GTX60332
- Zusätzliche Namen:
- RUNX1 translocation partner 1 , AML1-MTG8 , AML1T1 , CBFA2T1 , CDR , ETO , MTG8 , ZMYND2
- Anwendung:
- ChIP, ELISA
- Physischer Zustand:
- Liquid
- Spezies-Reaktivität:
- Human
- Aufreinigung:
- Unpurified
- Lagerbedingungen:
- -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
- Hersteller:
- Genetex
- Host:
- Rabbit
- Reaktivitäten:
- Human
- Buffer:
- Serum, 0.05% Sodium azide.
- Immunogen:
- Human ETO (runt-related transcription factor 1; translocated to, 1 (cyclin D-related)) using two KLH-conjugated synthetic peptides containing sequences from the N-terminal and the central region of the protein, respectively.
- Uniprot:
- Q06455
- Synonyme:
- acute myelogenous leukemia 1 translocation 1, cyclin-D related;AML1-MTG8;AML1T1;CBFA2T1;CDR;core-binding factor, runt domain, alpha subunit 2; translocated to, 1; cyclin D-related;Cyclin-D-related protein;eight twenty one protein;ETO;MTG8;myeloid translocation gene on 8q22;protein CBFA2T1;Protein ETO;Protein MTG8;runt related transcription factor 1; translocated to, 1 (cyclin D related);RUNX1 translocation partner 1;zinc finger MYND domain-containing protein 2;ZMYND2
- Weitere Details:
- This gene encodes a member of the myeloid translocation gene family which interact with DNA-bound transcription factors and recruit a range of corepressors to facilitate transcriptional repression. The t(8;21)(q22;q22) translocation is one of the most frequent karyotypic abnormalities in acute myeloid leukemia. The translocation produces a chimeric gene made up of the 5'-region of the runt-related transcription factor 1 gene fused to the 3'-region of this gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2010]
- Versandbedingungen:
- Blue Ice