IMPA1 antibody [AT2G5]

Eine Lieferung in diese Region ist nicht möglich.

SKU:: GTX57655
Zusätzliche Namen:: inositol monophosphatase 1 , IMP , IMPA , IMPA1
Anwendung:: Flow Cytometry, WB, IF, ICC
Konzentration:: 1 mg/ml
Physischer Zustand:: Liquid
Spezies-Reaktivität:: Human
Aufreinigung:: Protein A Purified
Lagerbedingungen:: -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
Hersteller:: Genetex
Host:: Mouse
Reaktivitäten:: Human, Mouse
Buffer:: PBS, 10% Glycerol, 0.02% Sodium azide.
Immunogen:: The clone AT2G5 is derived from hybridization of mouse F0 myeloma cells with spleen cells from BALB/c mice immunized with a recombinant human IMPA3 protein.
Klon:: AT2G5
Uniprot:: P29218
Synonyme:: D-galactose 1-phosphate phosphatase;IMP;IMP 1;IMPA;IMPase 1;inositol monophosphatase 1;inositol-1(or 4)-monophosphatase 1;inositol(myo)-1(or 4)-monophosphatase 1;lithium-sensitive myo-inositol monophosphatase A1;MRT59;myo-inositol monophosphatase 1;testicular tissue protein Li 94
Weitere Details:: This gene encodes an enzyme that dephosphorylates myo-inositol monophosphate to generate free myo-inositol, a precursor of phosphatidylinositol, and is therefore an important modulator of intracellular signal transduction via the production of the second messengers myoinositol 1,4,5-trisphosphate and diacylglycerol. This enzyme can also use myo-inositol-1,3-diphosphate, myo-inositol-1,4-diphosphate, scyllo-inositol-phosphate, glucose-1-phosphate, glucose-6-phosphate, fructose-1-phosphate, beta-glycerophosphate, and 2'-AMP as substrates. This enzyme shows magnesium-dependent phosphatase activity and is inhibited by therapeutic concentrations of lithium. Inhibition of inositol monophosphate hydroylosis and subsequent depletion of inositol for phosphatidylinositol synthesis may explain the anti-manic and anti-depressive effects of lithium administered to treat bipolar disorder. Alternative splicing results in multiple transcript variants encoding distinct isoforms. A pseudogene of this gene is also present on chromosome 8q21.13. [provided by RefSeq, Dec 2014]

Versandbedingungen:: Blue Ice