TFE3 antibody [IHC672]

Eine Lieferung in diese Region ist nicht möglich.

SKU:: GTX57200
Zusätzliche Namen:: Transcription Factor Binding To Ighm Enhancer 3 , Rccp2 , Rccx1 , Tfea , Bhlhe33 , Tfe3
Anwendung:: IHC-P
Physischer Zustand:: Liquid
Spezies-Reaktivität:: Human
Aufreinigung:: Protein A Purified
Lagerbedingungen:: 2-8[o]C Do not freeze.
Hersteller:: Genetex
Host:: Mouse
Reaktivitäten:: Human
Buffer:: Tris, 1% BSA, 0.09% Sodium azide.
Immunogen:: Recombinant Human TFE3 protein.
Klon:: IHC672
Synonyme:: bHLHe33;class E basic helix-loop-helix protein 33;RCCP2;RCCX1;TFEA;transcription factor E family, member A;transcription factor E3;transcription factor for IgH enhancer;transcription factor for immunoglobulin heavy-chain enhancer 3
Weitere Details:: The microphthalmia transcription factor/transcription factor E (MITF-TFE) family of basic helix-loop-helix leucine zipper (bHLH-Zip) transcription factors includes four family members: MITF, TFE3, TFEB and TFEC. The TEF3 protein encoded by this gene activates transcription through binding to the muE3 motif of the immunoglobulin heavy-chain enhancer. The TFEC protein forms heterodimers with the TEF3 protein and inhibits TFE3-dependent transcription activation. The TEF3 protein interacts with transcription regulators such as E2F3, SMAD3, and LEF-1, and is involved in TGF-beta-induced transcription, playing important roles in cell growth, proliferation, and osteoclast and macrophage differentiation. The TFE3 protein also activates hepatic IRS-2 gene, and induces hexokinase II (HK2) and insulin-induced gene 1 (INSIG1); it participates in insulin signaling and could be a therapeutic target for diabetes. This gene is also involved in chromosomal translocations, resulting in different fusion

Versandbedingungen:: Blue Ice