GTX56038
NEDL2 antibody
Eine Lieferung in diese Region ist nicht möglich.
- SKU:
- GTX56038
- Zusätzliche Namen:
- HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2 , NDHSAL , NEDL2
- Anwendung:
- WB, IF, ICC
- Physischer Zustand:
- Liquid
- Spezies-Reaktivität:
- Human
- Aufreinigung:
- Affinity Purified
- Lagerbedingungen:
- -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
- Hersteller:
- Genetex
- Host:
- Rabbit
- Reaktivitäten:
- Human, Mouse
- Buffer:
- 0.42% Potassium Phosphate, 0.87% NaCl, 30% Glycerol, 0.01% Sodium azide.
- Immunogen:
- KLH-conjugated synthetic peptide encompassing a sequence within the center region of NEDL2. The exact sequence is proprietary.
- Uniprot:
- Q9P2P5
- Synonyme:
- E3 ubiquitin-protein ligase HECW2;HECT-type E3 ubiquitin transferase HECW2;HECT, C2 and WW domain-containing protein 2;NDHSAL;NEDD4-like E3 ubiquitin-protein ligase 2;NEDD4-related E3 ubiquitin ligase NEDL2;NEDL2
- Weitere Details:
- This gene encodes a member of a family of E3 ubiquitin ligases which plays an important role in the proliferation, migration and differentiation of neural crest cells as a regulator of glial cell line-derived neurotrophic factor (GDNF)/Ret signaling. This gene also plays an important role in angiogenesis through stabilization of endothelial cell-to-cell junctions as a regulator of angiomotin-like 1 stability. The encoded protein contains an N-terminal calcium/lipid-binding (C2) domain involved in membrane targeting, two-four WW domains responsible for cellular localization and substrate recognition, and a C-terminal homologous with E6-associated protein C-terminus (HECT) catalytic domain. Naturally occurring mutations in this gene are associated with neurodevelopmental delay, hypotonia, and epilepsy. The decreased expression of this gene in the aganglionic colon is associated with Hirschsprung's disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2017]
- Versandbedingungen:
- Blue Ice