GTX55259
CDK2AP1 antibody
Eine Lieferung in diese Region ist nicht möglich.
- SKU:
- GTX55259
- Zusätzliche Namen:
- cyclin dependent kinase 2 associated protein 1 , DOC1 , DORC1 , ST19 , doc-1 , p12DOC-1
- Anwendung:
- WB
- Physischer Zustand:
- Liquid
- Spezies-Reaktivität:
- Human
- Aufreinigung:
- Affinity Purified
- Lagerbedingungen:
- -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
- Hersteller:
- Genetex
- Host:
- Rabbit
- Reaktivitäten:
- Human
- Buffer:
- 0.42% Potassium Phosphate, 0.87% NaCl, 30% Glycerol, 0.01% Sodium azide.
- Immunogen:
- KLH-conjugated synthetic peptide encompassing a sequence within the center region of CDK2AP1. The exact sequence is proprietary.
- Uniprot:
- O14519
- Synonyme:
- CDK2-associated protein 1;cyclin-dependent kinase 2-associated protein 1;deleted in oral cancer 1;Deleted in oral cancer-1;doc-1;DOC1;DORC1;p12DOC-1;putative oral cancer suppressor;ST19
- Weitere Details:
- The protein encoded by this gene is a cyclin-dependent kinase 2 (CDK2) -associated protein which is thought to negatively regulate CDK2 activity by sequestering monomeric CDK2, and targeting CDK2 for proteolysis. This protein was found to also interact with DNA polymerase alpha/primase and mediate the phosphorylation of the large p180 subunit, which suggests a regulatory role in DNA replication during the S-phase of the cell cycle. This protein also forms a core subunit of the nucleosome remodeling and histone deacetylation (NURD) complex that epigenetically regulates embryonic stem cell differentiation. This gene thus plays a role in both cell-cycle and epigenetic regulation. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2012]
- Versandbedingungen:
- Blue Ice