GTX55224
HEXB antibody
Eine Lieferung in diese Region ist nicht möglich.
- SKU:
- GTX55224
- Zusätzliche Namen:
- hexosaminidase subunit beta , ENC-1AS , HEL-248 , HEL-S-111
- Anwendung:
- WB, IHC-P, IF, ICC
- Physischer Zustand:
- Liquid
- Spezies-Reaktivität:
- Human
- Aufreinigung:
- Affinity Purified
- Lagerbedingungen:
- -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
- Hersteller:
- Genetex
- Host:
- Rabbit
- Reaktivitäten:
- Human
- Buffer:
- 0.42% Potassium Phosphate, 0.87% NaCl, 30% Glycerol, 0.01% Sodium azide.
- Immunogen:
- KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of HEXB. The exact sequence is proprietary.
- Uniprot:
- P07686
- Synonyme:
- beta-hexosaminidase beta-subunit;beta-hexosaminidase subunit beta;beta-N-acetylhexosaminidase subunit beta;cervical cancer proto-oncogene 7 protein;ENC-1AS;epididymis luminal protein 248;epididymis secretory protein Li 111;epididymis secretory sperm binding protein;HCC-7;HEL-248;HEL-S-111;hexosaminidase B (beta polypeptide);hexosaminidase subunit B;N-acetyl-beta-glucosaminidase subunit beta
- Weitere Details:
- Hexosaminidase B is the beta subunit of the lysosomal enzyme beta-hexosaminidase that, together with the cofactor GM2 activator protein, catalyzes the degradation of the ganglioside GM2, and other molecules containing terminal N-acetyl hexosamines. Beta-hexosaminidase is composed of two subunits, alpha and beta, which are encoded by separate genes. Both beta-hexosaminidase alpha and beta subunits are members of family 20 of glycosyl hydrolases. Mutations in the alpha or beta subunit genes lead to an accumulation of GM2 ganglioside in neurons and neurodegenerative disorders termed the GM2 gangliosidoses. Beta subunit gene mutations lead to Sandhoff disease (GM2-gangliosidosis type II). Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2014]
- Versandbedingungen:
- Blue Ice