GTX54845
Neurexin 1 antibody
Eine Lieferung in diese Region ist nicht möglich.
- SKU:
- GTX54845
- Zusätzliche Namen:
- neurexin 1 , Nrxn1b
- Anwendung:
- WB, IHC-Fr, IF, ICC, IM
- Konzentration:
- 0.8 mg/ml
- Physischer Zustand:
- Liquid
- Spezies-Reaktivität:
- Human, Rat
- Aufreinigung:
- Affinity Purified
- Lagerbedingungen:
- -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
- Hersteller:
- Genetex
- Host:
- Rabbit
- Reaktivitäten:
- Human, Mouse, Rat
- Buffer:
- PBS, 1% BSA, 0.05% Sodium azide.
- Immunogen:
- Peptide (C)KPRHQKDAKHPQMIK, corresponding to amino acid residues 546-560 (Extracellular, N-terminus) of rat Neurexin 1A Alpha (Accession : Q63372).
- Uniprot:
- Q63372
- Synonyme:
- 60S ribosomal protein L10a pseudogene;neurexin I-alpha;neurexin I-beta;neurexin-1;neurexin-1-alpha;neurexin-1-beta;non-processed neurexin I-alpha;Nrxn1b
- Weitere Details:
- This gene encodes a single-pass type I membrane protein that belongs to the neurexin family. Neurexins are synaptic transmembrane receptors that bind endogenous ligands that include neuroligins, dystroglycan, and neurexophilins. Neurexin complexes are required for efficient neurotransmission and are involved in synaptogenesis. In vertebrates, alternate promoter usage results in multiple isoform classes, of which the alpha and beta classes are the best characterized. In humans, allelic variants in this gene are associated with Pitt-Hopkins-like syndrome-2, while deletions have been associated with autism and schizophrenia. Mouse knockouts display decreased spontaneous and evoked vesicle release resulting in impaired synaptic transmission. In addition, knockout mice show altered social approach, reduced social investigation, reduced locomotor activity, and in males, increased aggression. [provided by RefSeq, Nov 2016]
- Versandbedingungen:
- Blue Ice