GTX54545
POLH antibody
Eine Lieferung in diese Region ist nicht möglich.
- SKU:
- GTX54545
- Zusätzliche Namen:
- DNA polymerase eta , RAD30 , RAD30A , XP-V , XPV
- Anwendung:
- WB, IF, ICC
- Physischer Zustand:
- Liquid
- Spezies-Reaktivität:
- Human
- Aufreinigung:
- Affinity Purified
- Lagerbedingungen:
- -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
- Hersteller:
- Genetex
- Host:
- Rabbit
- Reaktivitäten:
- Human
- Buffer:
- PBS, 50% Glycerol, 0.02% Sodium azide.
- Immunogen:
- Recombinant fusion protein containing a sequence corresponding to amino acids 20-320 of human POLH (NP_006493.1).
- Uniprot:
- Q9Y253
- Synonyme:
- DNA polymerase eta;polymerase (DNA directed), eta;polymerase (DNA) eta;RAD30;RAD30 homolog A;RAD30A;xeroderma pigmentosum variant type protein;XP-V;XPV
- Weitere Details:
- This gene encodes a member of the Y family of specialized DNA polymerases. It copies undamaged DNA with a lower fidelity than other DNA-directed polymerases. However, it accurately replicates UV-damaged DNA; when thymine dimers are present, this polymerase inserts the complementary nucleotides in the newly synthesized DNA, thereby bypassing the lesion and suppressing the mutagenic effect of UV-induced DNA damage. This polymerase is thought to be involved in hypermutation during immunoglobulin class switch recombination. Mutations in this gene result in XPV, a variant type of xeroderma pigmentosum. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2014]
- Versandbedingungen:
- Blue Ice