MASP1/3 antibody [2B11]

Eine Lieferung in diese Region ist nicht möglich.

SKU:: GTX54445
Zusätzliche Namen:: CRARF,CRARF1,MAP1,MASP,MASP1,MASP3,MAp44,PRSS5,RaRF,mannan binding lectin serine peptidase 1,3MC1
Anwendung:: ELISA, WB, IP
Konzentration:: 100 ug/ml
Physischer Zustand:: Liquid
Spezies-Reaktivität:: Human
Aufreinigung:: Purified
Lagerbedingungen:: 2-8[o]C
Hersteller:: Genetex
Host:: Mouse
Reaktivitäten:: Human
Buffer:: Filter-sterilized PBS, 0.1% BSA, 0.02% Sodium azide.
Immunogen:: mannan binding lectin serine peptidase 1
Klon:: 2B11
Uniprot:: P48740
Synonyme:: 3MC1;C4/C2 activating component of Ra-reactive factor;complement factor MASP-3;complement-activating component of Ra-reactive factor;CRARF;CRARF1;mannan binding lectin serine peptidase 1;mannan-binding lectin serine protease 1;mannose-associated serine protease 1;mannose-binding lectin-associated serine protease 1;mannose-binding protein-associated serine protease;MAP-1;MAP1;MAp44;MASP;MASP-3;MASP3;PRSS5;Ra-reactive factor serine protease p100;RaRF;serine protease 5
Weitere Details:: This gene encodes a serine protease that functions as a component of the lectin pathway of complement activation. The complement pathway plays an essential role in the innate and adaptive immune response. The encoded protein is synthesized as a zymogen and is activated when it complexes with the pathogen recognition molecules of lectin pathway, the mannose-binding lectin and the ficolins. This protein is not directly involved in complement activation but may play a role as an amplifier of complement activation by cleaving complement C2 or by activating another complement serine protease, MASP-2. The encoded protein is also able to cleave fibrinogen and factor XIII and may may be involved in coagulation. A splice variant of this gene which lacks the serine protease domain functions as an inhibitor of the complement pathway. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Apr 2010]

Versandbedingungen:: Blue Ice