KPNA2 antibody

Eine Lieferung in diese Region ist nicht möglich.

SKU:: GTX54349
Zusätzliche Namen:: karyopherin subunit alpha 2 , IPOA1 , QIP2 , RCH1 , SRP1-alpha , SRP1alpha
Anwendung:: WB, IP
Physischer Zustand:: Liquid
Spezies-Reaktivität:: Human
Aufreinigung:: Affinity Purified
Lagerbedingungen:: -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
Hersteller:: Genetex
Host:: Rabbit
Reaktivitäten:: Human, Mouse
Buffer:: PBS, 50% Glycerol, 0.02% Sodium azide.
Immunogen:: Recombinant fusion protein containing a sequence corresponding to amino acids 1-290 of human KPNA2 (NP_002257.1).
Uniprot:: P52292
Synonyme:: importin subunit alpha-1;importin subunit alpha-2;importin-alpha-P1;IPOA1;karyopherin alpha 2 (RAG cohort 1, importin alpha 1);Karyopherin subunit alpha-2;pendulin;QIP2;RAG cohort protein 1;RCH1;SRP1-alpha;SRP1alpha
Weitere Details:: The import of proteins into the nucleus is a process that involves at least 2 steps. The first is an energy-independent docking of the protein to the nuclear envelope and the second is an energy-dependent translocation through the nuclear pore complex. Imported proteins require a nuclear localization sequence (NLS) which generally consists of a short region of basic amino acids or 2 such regions spaced about 10 amino acids apart. Proteins involved in the first step of nuclear import have been identified in different systems. These include the Xenopus protein importin and its yeast homolog, SRP1 (a suppressor of certain temperature-sensitive mutations of RNA polymerase I in Saccharomyces cerevisiae), which bind to the NLS. KPNA2 protein interacts with the NLSs of DNA helicase Q1 and SV40 T antigen and may be involved in the nuclear transport of proteins. KPNA2 also may play a role in V(D)J recombination. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]

Versandbedingungen:: Blue Ice