GTX54039
DDB2 antibody
Eine Lieferung in diese Region ist nicht möglich.
- SKU:
- GTX54039
- Zusätzliche Namen:
- damage specific DNA binding protein 2 , DDBB , UV-DDB2 , XPE
- Anwendung:
- WB, IF, ICC
- Physischer Zustand:
- Liquid
- Spezies-Reaktivität:
- Human
- Aufreinigung:
- Affinity Purified
- Lagerbedingungen:
- -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
- Hersteller:
- Genetex
- Host:
- Rabbit
- Reaktivitäten:
- Human, Mouse, Rat
- Buffer:
- PBS, 50% Glycerol, 0.02% Sodium azide.
- Immunogen:
- Recombinant fusion protein containing a sequence corresponding to amino acids 1-315 of human DDB2 (NP_000098.1).
- Uniprot:
- Q92466
- Synonyme:
- damage-specific DNA binding protein 2, 48kDa;Damage-specific DNA-binding protein 2;DDB p48 subunit;DDBB;DNA damage-binding protein 2;UV-damaged DNA-binding protein 2;UV-DDB 2;UV-DDB2;xeroderma pigmentosum group E protein;XPE
- Weitere Details:
- This gene encodes a protein that is necessary for the repair of ultraviolet light-damaged DNA. This protein is the smaller subunit of a heterodimeric protein complex that participates in nucleotide excision repair, and this complex mediates the ubiquitylation of histones H3 and H4, which facilitates the cellular response to DNA damage. This subunit appears to be required for DNA binding. Mutations in this gene cause xeroderma pigmentosum complementation group E, a recessive disease that is characterized by an increased sensitivity to UV light and a high predisposition for skin cancer development, in some cases accompanied by neurological abnormalities. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]
- Versandbedingungen:
- Blue Ice