GTX53915
Cbl-b antibody
Eine Lieferung in diese Region ist nicht möglich.
- SKU:
- GTX53915
- Zusätzliche Namen:
- Cbl proto-oncogene B , Cbl-b , Nbla00127 , RNF56
- Anwendung:
- WB
- Physischer Zustand:
- Liquid
- Spezies-Reaktivität:
- Human
- Aufreinigung:
- Affinity Purified
- Lagerbedingungen:
- -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
- Hersteller:
- Genetex
- Host:
- Rabbit
- Reaktivitäten:
- Human, Mouse, Rat
- Buffer:
- PBS, 50% Glycerol, 0.05% ProClin 300.
- Immunogen:
- Recombinant fusion protein containing a sequence corresponding to amino acids 1-350 of human CBLB (NP_733762.2).
- Uniprot:
- Q13191
- Synonyme:
- Cas-Br-M (murine) ecotropic retroviral transforming sequence b;casitas B-lineage lymphoma proto-oncogene b;Cbl proto-oncogene B, E3 ubiquitin protein ligase;Cbl proto-oncogene, E3 ubiquitin protein ligase B;Cbl-b;E3 ubiquitin-protein ligase CBL-B;Nbla00127;RING finger protein 56;RING-type E3 ubiquitin transferase CBL-B;RNF56;SH3-binding protein CBL-B;signal transduction protein CBL-B
- Weitere Details:
- This gene encodes an E3 ubiquitin-protein ligase which promotes proteosome-mediated protein degradation by transferring ubiquitin from an E2 ubiquitin-conjugating enzyme to a substrate. The encoded protein is involved in the regulation of immune response by limiting T-cell receptor, B-cell receptor, and high affinity immunoglobulin epsilon receptor activation. Studies in mouse suggest that this gene is involved in antifungal host defense and that its inhibition leads to increased fungal killing. Manipulation of this gene may be beneficial in implementing immunotherapies for a variety of conditions, including cancer, autoimmune diseases, allergies, and infections. [provided by RefSeq, Sep 2017]
- Versandbedingungen:
- Blue Ice