TREM-2b antibody [5J46]

Eine Lieferung in diese Region ist nicht möglich.

SKU:: GTX53229
Anwendung:: Flow Cytometry, IHC, WB, IF, ICC
Physischer Zustand:: Liquid
Spezies-Reaktivität:: Mouse
Aufreinigung:: protein a/g purified
Lagerbedingungen:: -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
Hersteller:: Genetex
Host:: Rat
Reaktivitäten:: Mouse
Buffer:: PBS, no preservatives.
Immunogen:: Mouse recombinant protein of the extracellular domain of TREM-2b
Klon:: 5J46
Uniprot:: Q99NH8
Synonyme:: Trem;TREM-2;Trem2a;Trem2b;Trem2c;triggering receptor expressed on monocytes 2;triggering receptor expressed on myeloid cells 2;triggering receptor expressed on myeloid cells 2a;triggering receptor expressed on myeloid cells 2b;triggering receptor expressed on myeloid cells 2c
Weitere Details:: The protein encoded by this gene is part of the immunoglobulin and lectin-like superfamily and functions as part of the innate immune system. This gene forms part of a cluster of genes on mouse chromosome 17 thought to be involved in innate immunity. This protein associates with the adaptor protein Dap-12 and recruits several factors, such as kinases and phospholipase C-gamma, to form a receptor signaling complex that activates myeloid cells, including dendritic cells and microglia. In humans homozygous loss-of-function mutations in this gene cause Nasu-Hakola disease and mutations in this gene may be risk factors to the development of Alzheimer's disease. In mouse mutations of this gene serve as a pathophysiological model for polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (Nasu-Hakola disease) and for inflammatory bowel disease. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Jan 2013]

Versandbedingungen:: Blue Ice