GDNF antibody [12F9]

Eine Lieferung in diese Region ist nicht möglich.

SKU:: GTX52761
Zusätzliche Namen:: ATF , ATF1 , ATF2 , GDNF , HFB1GDNF , HSCR3 , glial cell derived neurotrophic factor
Anwendung:: WB, FuncS, Neutralisation
Konzentration:: 500 ug/ml
Physischer Zustand:: Liquid
Spezies-Reaktivität:: Human
Aufreinigung:: Protein G Purified
Lagerbedingungen:: -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
Hersteller:: Genetex
Host:: Mouse
Reaktivitäten:: Human
Buffer:: PBS, no preservatives.
Immunogen:: Human recombinant GDNF
Klon:: 12F9
Uniprot:: P39905
Synonyme:: astrocyte-derived trophic factor;ATF;ATF1;ATF2;glial cell line-derived neurotrophic factor;HFB1-GDNF;HSCR3
Weitere Details:: This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. The recombinant form of this protein, a highly conserved neurotrophic factor, was shown to promote the survival and differentiation of dopaminergic neurons in culture, and was able to prevent apoptosis of motor neurons induced by axotomy. This protein is a ligand for the product of the RET (rearranged during transfection) protooncogene. Mutations in this gene may be associated with Hirschsprung disease and Tourette syndrome. This gene encodes multiple protein isoforms that may undergo similar proteolytic processing. [provided by RefSeq, Aug 2016]

Versandbedingungen:: Blue Ice