GTX52538
alpha 2 Macroglobulin antibody [4H44]
Eine Lieferung in diese Region ist nicht möglich.
- SKU:
- GTX52538
- Zusätzliche Namen:
- A2M , A2MD , CPAMD5 , FWP007 , S8637 , alpha2macroglobulin , alpha2 macroglobulin , alpha 2 Macroglobulin , alpha-2-macroglobulin
- Anwendung:
- WB
- Konzentration:
- 500 ug/ml
- Physischer Zustand:
- Liquid
- Spezies-Reaktivität:
- Human
- Aufreinigung:
- Protein G Purified
- Lagerbedingungen:
- -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
- Hersteller:
- Genetex
- Host:
- Mouse
- Reaktivitäten:
- Human
- Buffer:
- PBS, no preservatives.
- Immunogen:
- Human recombinant A Alpha -2 macroglobulin
- Klon:
- 4H44
- Uniprot:
- P01023
- Synonyme:
- A2MD;alpha-2-M;alpha-2-macroglobulin;C3 and PZP-like alpha-2-macroglobulin domain-containing protein 5;CPAMD5;FWP007;S863-7
- Weitere Details:
- The protein encoded by this gene is a protease inhibitor and cytokine transporter. It uses a bait-and-trap mechanism to inhibit a broad spectrum of proteases, including trypsin, thrombin and collagenase. It can also inhibit inflammatory cytokines, and it thus disrupts inflammatory cascades. Mutations in this gene are a cause of alpha-2-macroglobulin deficiency. This gene is implicated in Alzheimer's disease (AD) due to its ability to mediate the clearance and degradation of A-beta, the major component of beta-amyloid deposits. A related pseudogene, which is also located on the p arm of chromosome 12, has been identified. [provided by RefSeq, Nov 2016]
- Versandbedingungen:
- Blue Ice