GTX48735
Mre11 antibody
Eine Lieferung in diese Region ist nicht möglich.
- SKU:
- GTX48735
- Zusätzliche Namen:
- MRE11A homolog A, double strand break repair nuclease , Mre11 , Mre11b
- Anwendung:
- ELISA, WB
- Konzentration:
- 1.05 mg/ml
- Physischer Zustand:
- Liquid
- Spezies-Reaktivität:
- Mouse
- Aufreinigung:
- Affinity Purified
- Lagerbedingungen:
- -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
- Hersteller:
- Genetex
- Host:
- Rabbit
- Reaktivitäten:
- Mouse
- Buffer:
- 20mM Potassium Phosphate, 150mM NaCl, 0.01% Sodium azide.
- Immunogen:
- Recombinant protein corresponding to amino acids 68-706 of mouse Mre11 protein.
- Uniprot:
- Q61216
- Synonyme:
- double-strand break repair protein MRE11;double-strand break repair protein MRE11A;meiotic recombination 11 homolog 1;meiotic recombination 11 homolog A;mmMRE11A;Mre11;MRE11 homolog 1;MRE11 homolog A;Mre11b
- Weitere Details:
- Mre11 is a component of the MRN complex (Mre11/Rad50/Nbs1), which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis. The complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11A. RAD50 may be required to bind DNA ends and hold them in close proximity. This could facilitate searches for short or long regions of sequence homology in the recombining DNA templates, and may also stimulate the activity of DNA ligases and/or restrict the nuclease activity of MRE11A to prevent nucleolytic degradation past a given point. The complex may also be required for DNA damage signaling via activation of the ATM kinase. In telomeres the MRN complex may
- Versandbedingungen:
- Blue Ice