GTX48712
eIF3e antibody
Eine Lieferung in diese Region ist nicht möglich.
- SKU:
- GTX48712
- Zusätzliche Namen:
- eukaryotic translation initiation factor 3, subunit E , 48kDa , Eif3s6 , Int6 , eIF3-p46 , eIF3-p48
- Anwendung:
- ELISA, WB
- Konzentration:
- 0.8 mg/ml
- Physischer Zustand:
- Liquid
- Spezies-Reaktivität:
- Mouse
- Aufreinigung:
- Affinity Purified
- Lagerbedingungen:
- -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
- Hersteller:
- Genetex
- Host:
- Rabbit
- Reaktivitäten:
- Human, Mouse
- Buffer:
- 20mM Potassium Phosphate, 150mM NaCl, 0.01% Sodium azide.
- Immunogen:
- Synthetic peptide corresponding to a region near the C-terminus of mouse EIF3S6/Int6.
- Uniprot:
- P60229
- Synonyme:
- 48kD;48kDa;eIF-3 p48;Eif3;eIF3-p;eIF3-p46;eIF3-p48;eIF3e;Eif3s6;Eukaryotic translation initiation factor 3 subunit 6;eukaryotic translation initiation factor 3 subunit E;eukaryotic translation initiation factor 3, subunit 6 48kDa;In;Int6;mammary tumor integration site 6;mammary tumor-associated protein INT-6;MMTV integration site 6;viral integration site protein INT-6
- Weitere Details:
- Int6 is a candidate tumor suppressor in multiple neoplasms, and in particular, breast and lung cancers. The Int6 locus was initially identified as a common insertion site (CIS) in a genetic screen for transforming sequences in a breast cancer mouse model system. Insertion of mouse mammary tumor virus (MMTV) into this locus results in the production of an amino-terminal truncated gene product. Expression of the truncated Int6 product corresponds to cellular transformation in both in vivo and in vitro systems. This gene product plays a role in regulating translation initiation and is a component of the eIF3 translation initiation complex.There is evidence that suggests that Int6 may impart a negative role in the general translational machinery while promoting an increase in the expression of a subset of stress-responsive genes. Taken together, it is of great interest to further study the mechanism by which Int6 is involved in regulating cell growth.
- Versandbedingungen:
- Blue Ice