GTX48703
Nogo A antibody
Eine Lieferung in diese Region ist nicht möglich.
- SKU:
- GTX48703
- Zusätzliche Namen:
- reticulon 4 , ASY , NI220/250 , NOGO , NSP , NSP-CL , Nbla00271 , Nbla10545 , RTN-X , RTN4-A , RTN4-B1 , RTN4-B2 , RTN4-C
- Anwendung:
- ELISA, IHC, WB, IF, ICC
- Konzentration:
- 1 mg/ml
- Physischer Zustand:
- Liquid
- Spezies-Reaktivität:
- Human
- Aufreinigung:
- Affinity Purified
- Lagerbedingungen:
- -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
- Hersteller:
- Genetex
- Host:
- Rabbit
- Reaktivitäten:
- Human, Mouse, Rat
- Buffer:
- 20mM Potassium Phosphate, 150mM NaCl, 0.02% Sodium Azide.
- Immunogen:
- This affinity purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to an internal region of human Nogo A protein.
- Uniprot:
- Q9NQC3
- Synonyme:
- ASY;foocen;Human NogoA;My043 protein;Nbla00271;Nbla10545;neurite growth inhibitor 220;neurite outgrowth inhibitor;Neuroendocrine-specific protein;neuroendocrine-specific protein C homolog;NI220/250;NOGO;NSP;NSP-CL;reticulon 5;reticulon-4;Reticulon-5;RTN-X;RTN4-A;RTN4-B1;RTN4-B2;RTN4-C
- Weitere Details:
- NogoA is a member of a family of integral membrane proteins termed reticulons that are thought to be involved in numerous disorders including neurodegenerative diseases. Reticulon proteins are known to regulate many cellular processes and interact with multiple proteins and receptors such as BACE. NogoA was initially identified as a myelin-associated neurite outgrowth inhibitor. It is highly expressed in oligodendrocytes in the white matter of the CNS; blocking its activity with antibodies or other factors results in improved axon regrowth and functional recovery in experimental CNS lesion models. NogoA has also been suggested to play a role in neurodegenerative diseases such as Amyotrophic lateral sclerosis, in which case NogoA is found at elevated levels in postmortem muscular samples, and multiple sclerosis (MS), in which case autoantibodies to NogoA have been found in serum and cerebrospinal fluid in MS patients.
- Versandbedingungen:
- Blue Ice