LEFTY2 antibody [7C5G1H6H10]

Eine Lieferung in diese Region ist nicht möglich.

SKU:: GTX48643
Zusätzliche Namen:: left-right determination factor 2 , EBAF , LEFTA , LEFTYA , TGFB4
Anwendung:: ELISA, WB
Konzentration:: 1 mg/ml
Physischer Zustand:: Liquid
Spezies-Reaktivität:: Human
Aufreinigung:: Protein A Purified
Lagerbedingungen:: -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
Hersteller:: Genetex
Host:: Mouse
Reaktivitäten:: Human
Buffer:: 20mM Potassium Phosphate, 150mM NaCl, 0.01% Sodium azide.
Immunogen:: Recombinant form of 6X His-tagged human LEFTY.
Klon:: 7C5G1H6H10
Uniprot:: O00292
Synonyme:: EBAF;endometrial bleeding-associated factor;left-right determination factor 2;left-right determination factor A;LEFTA;LEFTYA;protein lefty-2;protein lefty-A;TGF-beta-4;TGFB4;transforming growth factor beta-4
Weitere Details:: During vertebrate embryogenesis, a left-right axis is established. Secreted growth factors of the TGF-beta family, including gene products derived from nodal, lefty-1 and lefty-2, play crucial roles in establishing left-right asymmetries. TGF-beta (Transforming growth factor-beta) is a pleiotropic cytokine that regulates growth and differentiation of diverse types of cells. TGF-beta actions are directed by ligand-induced activation of TGF-beta receptors. Complexes formed move into the nucleus, where they act as components of a transcriptional complex. Lefty, a novel member of the TGF-beta superfamily, inhibits TGF-beta signaling. Lefty acts to inhibit phosphorylation of Smad2 following activation of the TGF-beta receptor. Lefty also inhibits events downstream from R-Smad phosphorylation. Lefty provides a repressed state of TGF-beta-responsive genes. The Lefty family is comprised of Lefty 1 and Lefty 2 in mouse, and Lefty A and Lefty B in humans. Members of the TGF-beta superfamily require processing for their activation. Cleavage is therefore an essential step for Lefty activation. Lefty is synthesized as a large inactive precursor (42 Kda) that must be endoproteolytically processed to release the bioactive polypeptide (28 kDa and 34 kDa forms). The 28kDa form induces MAPK activity.

Versandbedingungen:: Blue Ice