GTX48477
Cripto antibody
Eine Lieferung in diese Region ist nicht möglich.
- SKU:
- GTX48477
- Zusätzliche Namen:
- teratocarcinoma-derived growth factor 1 , CR , CR-1 , CRGF , CRIPTO
- Anwendung:
- ELISA, WB, IHC-P
- Konzentration:
- 0.97 mg/ml
- Physischer Zustand:
- Liquid
- Spezies-Reaktivität:
- Human
- Aufreinigung:
- Affinity Purified
- Lagerbedingungen:
- -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
- Hersteller:
- Genetex
- Host:
- Rabbit
- Reaktivitäten:
- Human, Mouse
- Buffer:
- 20mM Potassium Phosphate, 150mM NaCl, 0.01% Sodium azide.
- Immunogen:
- Synthetic peptide corresponding to an internal sequence of human Cripto-1 protein.
- Uniprot:
- P13385
- Synonyme:
- CR;CR-1;CRGF;CRIPTO;cripto-1 growth factor;epidermal growth factor-like cripto protein CR1;teratocarcinoma-derived growth factor 1
- Weitere Details:
- Human Cripto-1 (CR-1), also known as Teratocarcinoma-derived growth factor 1 (TDGF1), is a member of the epidermal growth factor (EGF)-GFC family and has been implicated in both embryogenesis and carcinogenesis. During early vertebrate development, CR-1 functions as a co-receptor for Nodal, a transforming growth factor b (TGFb) family member, and is essential for mesoderm and endoderm formation and anterior-posterior and left-right axis establishment. In adult tissues, CR-1 is expressed at a low level in all stages of mammary gland development, and expression increases during pregnancy and lactation. Over-expression of CR-1 in mouse mammary epithelial cells leads to their transformation in vitro, and when injected in mammary glands, CR-1 produces ductal hyperplasias.
- Versandbedingungen:
- Blue Ice