GTX46863
SLC12A3 antibody, C-term
Eine Lieferung in diese Region ist nicht möglich.
- SKU:
- GTX46863
- Zusätzliche Namen:
- solute carrier family 12 member 3 , NCC , NCCT , TSC
- Anwendung:
- WB
- Konzentration:
- 0.5-1 mg/ml
- Physischer Zustand:
- Liquid
- Spezies-Reaktivität:
- Human
- Aufreinigung:
- Affinity Purified
- Lagerbedingungen:
- -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
- Hersteller:
- Genetex
- Host:
- Rabbit
- Reaktivitäten:
- Human
- Buffer:
- PBS, 2% Sucrose, 0.09% Sodium azide.
- Immunogen:
- A synthetic peptide corresponding to an C-terminal region of Human SLC12A3.
- Uniprot:
- P55017
- Synonyme:
- Na-Cl cotransporter;Na-Cl symporter;NaCl electroneutral thiazide-sensitive cotransporter;NCC;NCCT;solute carrier family 12 (sodium/chloride transporter), member 3;solute carrier family 12 member 3;thiazide-sensitive Na-Cl cotransporter;thiazide-sensitive sodium-chloride cotransporter;TSC
- Weitere Details:
- This gene encodes a renal thiazide-sensitive sodium-chloride cotransporter that is important for electrolyte homeostasis. This cotransporter mediates sodium and chloride reabsorption in the distal convoluted tubule. Mutations in this gene cause Gitelman syndrome, a disease similar to Bartter's syndrome, that is characterized by hypokalemic alkalosis combined with hypomagnesemia, low urinary calcium, and increased renin activity associated with normal blood pressure. This cotransporter is the target for thiazide diuretics that are used for treating high blood pressure. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
- Versandbedingungen:
- Blue Ice