AF4 antibody, N-term

Eine Lieferung in diese Region ist nicht möglich.

SKU:: GTX44608
Zusätzliche Namen:: AF4/FMR2 family, member 1 , 9630032B01Rik , AW319193 , Af4 , Mllt2h , Rob
Anwendung:: WB
Konzentration:: 0.5-1 mg/ml
Physischer Zustand:: Liquid
Spezies-Reaktivität:: Mouse
Aufreinigung:: Affinity Purified
Lagerbedingungen:: -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
Hersteller:: Genetex
Host:: Rabbit
Reaktivitäten:: Mouse
Buffer:: PBS, 2% Sucrose, 0.09% Sodium azide.
Immunogen:: A synthetic peptide corresponding to a N-terminal region of Mouse AF4.
Synonyme:: 9630032B01Rik;Af;Af4;AF4/FMR2 family member 1;AW319193;homolog of human MLLT2 unidentified;Mllt;Mllt2h;myeloid/lymphoid or mixed-lineage leukemia translocated to 2 homolog;protein AF-4;proto-oncogene AF4;R;Rob;robotic
Weitere Details:: This gene encodes a member of the AF4/ lymphoid nuclear protein related to the Fragile X E syndrome (FRAXE) family of proteins, which have been implicated in human childhood lymphoblastic leukemia, fragile chromosome X intellectual disability, and ataxia. It is the prevalent mixed-lineage leukemia fusion gene associated with spontaneous acute lymphoblastic leukemia. Members of this family have three conserved domains: an N-terminal homology domain, an AF4/ lymphoid nuclear protein domain, and a C-terminal homology domain. Knockout of the mouse gene by homologous recombination severely affects early events in lymphopoiesis, including precursor proliferation or recruitment, but is dispensable for terminal differentiation. In addition, an autosomal dominant missense mutation results in several phenotypes including ataxia and adult-onset Purkinje cell loss in the cerebellum, indicating a role in Purkinje cell maintenance and function. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2017]

Versandbedingungen:: Blue Ice