GTX38531
RUNX2 antibody
Eine Lieferung in diese Region ist nicht möglich.
- SKU:
- GTX38531
- Zusätzliche Namen:
- runt related transcription factor 2 , AML3 , CBF-alpha-1 , CBFA1 , CCD , CCD1 , CLCD , OSF-2 , OSF2 , PEA2aA , PEBP2aA
- Anwendung:
- WB, IHC-P
- Physischer Zustand:
- Liquid
- Spezies-Reaktivität:
- Human
- Aufreinigung:
- Affinity Purified
- Lagerbedingungen:
- -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
- Hersteller:
- Genetex
- Host:
- Rabbit
- Reaktivitäten:
- Human, Rat
- Buffer:
- 0.001% Na₂HPO₄, 0.0045% NaCl, 0.025% BSA, 0.00025% Thimerosal, 0.00025% Sodium azide.
- Immunogen:
- A synthetic peptide corresponding to a sequence in the middle region of human RUNX2 (244-258aa DRLSDLGRIPHPSMR), identical to the related rat and mouse sequences.
- Uniprot:
- Q13950
- Synonyme:
- acute myeloid leukemia 3 protein;AML3;CBF-alpha-1;CBFA1;CCD;CCD1;CLCD;Core-binding factor subunit alpha-1;core-binding factor, runt domain, alpha subunit 1;oncogene AML-3;OSF-2;OSF2;osteoblast-specific transcription factor 2;PEA2-alpha A;PEA2aA;PEBP2-alpha A;PEBP2aA;polyomavirus enhancer-binding protein 2 alpha A subunit;runt related transcription factor 2;runt-related transcription factor 2;SL3-3 enhancer factor 1 alpha A subunit;SL3/AKV core-binding factor alpha A subunit
- Weitere Details:
- This gene is a member of the RUNX family of transcription factors and encodes a nuclear protein with an Runt DNA-binding domain. This protein is essential for osteoblastic differentiation and skeletal morphogenesis and acts as a scaffold for nucleic acids and regulatory factors involved in skeletal gene expression. The protein can bind DNA both as a monomer or, with more affinity, as a subunit of a heterodimeric complex. Two regions of potential trinucleotide repeat expansions are present in the N-terminal region of the encoded protein, and these and other mutations in this gene have been associated with the bone development disorder cleidocranial dysplasia (CCD). Transcript variants that encode different protein isoforms result from the use of alternate promoters as well as alternate splicing. [provided by RefSeq, Jul 2016]
- Versandbedingungen:
- Blue Ice