GTX37204
Phospholamban antibody
Eine Lieferung in diese Region ist nicht möglich.
- SKU:
- GTX37204
- Zusätzliche Namen:
- phospholamban , CMD1P , CMH18 , PLB
- Anwendung:
- WB
- Physischer Zustand:
- Liquid
- Spezies-Reaktivität:
- Human, Rat
- Aufreinigung:
- Affinity Purified
- Lagerbedingungen:
- -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
- Hersteller:
- Genetex
- Host:
- Rabbit
- Reaktivitäten:
- Rat
- Buffer:
- 0.001% Na₂HPO₄, 0.0045% NaCl, 0.025% BSA, 0.00025% Thimerosal, 0.00025% Sodium azide.
- Immunogen:
- A synthetic peptide corresponding to a sequence at the N-terminus of human PLN(2-16aa EKVQYLTRSAIRRAS), identical to the related rat and mouse sequences.
- Uniprot:
- P26678
- Synonyme:
- cardiac phospholamban;CMD1P;CMH18;PLB
- Weitere Details:
- The protein encoded by this gene is found as a pentamer and is a major substrate for the cAMP-dependent protein kinase in cardiac muscle. The encoded protein is an inhibitor of cardiac muscle sarcoplasmic reticulum Ca(2+)-ATPase in the unphosphorylated state, but inhibition is relieved upon phosphorylation of the protein. The subsequent activation of the Ca(2+) pump leads to enhanced muscle relaxation rates, thereby contributing to the inotropic response elicited in heart by beta-agonists. The encoded protein is a key regulator of cardiac diastolic function. Mutations in this gene are a cause of inherited human dilated cardiomyopathy with refractory congestive heart failure, and also familial hypertrophic cardiomyopathy. [provided by RefSeq, Apr 2016]
- Versandbedingungen:
- Blue Ice