![Thymidylate synthase antibody [TMS715]](https://www.genetex.com/upload/website/prouct_img/normal/GTX35114/GTX35114_20200115_IHC-P_1218_w_23060801_392.webp)
GTX35114
Thymidylate synthase antibody [TMS715]
Eine Lieferung in diese Region ist nicht möglich.
- SKU:
- GTX35114
- Zusätzliche Namen:
- HST422 , TMS , TS , TYMS , thymidylate synthetase , Thymidylate Synthase
- Anwendung:
- IHC-P
- Konzentration:
- 0.2 mg/ml
- Physischer Zustand:
- Liquid
- Spezies-Reaktivität:
- Human
- Aufreinigung:
- protein a/g purified
- Lagerbedingungen:
- 2-8[o]C
- Hersteller:
- Genetex
- Host:
- Mouse
- Reaktivitäten:
- Human
- Buffer:
- PBS, 0.05% BSA, 0.05% Sodium azide.
- Immunogen:
- Recombinant human thymidylate synthase
- Klon:
- TMS715
- Uniprot:
- P04818
- Synonyme:
- HST422;thymidylate synthase;TMS;TS;TSase
- Weitere Details:
- Thymidylate synthase catalyzes the methylation of deoxyuridylate to deoxythymidylate using, 10-methylenetetrahydrofolate (methylene-THF) as a cofactor. This function maintains the dTMP (thymidine-5-prime monophosphate) pool critical for DNA replication and repair. The enzyme has been of interest as a target for cancer chemotherapeutic agents. It is considered to be the primary site of action for 5-fluorouracil, 5-fluoro-2-prime-deoxyuridine, and some folate analogs. Expression of this gene and that of a naturally occurring antisense transcript, mitochondrial enolase superfamily member 1 (GeneID:55556), vary inversely when cell-growth progresses from late-log to plateau phase. Polymorphisms in this gene may be associated with etiology of neoplasia, including breast cancer, and response to chemotherapy. [provided by RefSeq, Aug 2017]
- Versandbedingungen:
- Blue Ice