MALT1 antibody [SPM578]

Eine Lieferung in diese Region ist nicht möglich.

SKU:: GTX34813
Zusätzliche Namen:: IMD12 , MALT1 , MALT1 paracaspase , MLT , MLT1 , PCASP1
Anwendung:: WB, IHC-P
Konzentration:: 0.2 mg/ml
Physischer Zustand:: Liquid
Spezies-Reaktivität:: Human
Aufreinigung:: protein a/g purified
Lagerbedingungen:: -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
Hersteller:: Genetex
Host:: Mouse
Reaktivitäten:: Human
Buffer:: PBS, 0.05% BSA, 0.05% Sodium azide.
Immunogen:: Human MALT1 recombinant fragment (aa701-808)
Klon:: SPM578
Uniprot:: Q9UDY8
Synonyme:: caspase-like protein;IMD12;MALT lymphoma-associated translocation;MALT1 protease;MLT;MLT1;mucosa associated lymphoid tissue lymphoma translocation gene 1;mucosa-associated lymphoid tissue lymphoma translocation protein 1;Paracaspase;paracaspase-1;PCASP1
Weitere Details:: This gene encodes a caspase-like protease that plays a role in BCL10-induced activation of NF-kappaB. The protein is a component of the CARMA1-BCL10-MALT1 (CBM) signalosome that triggers NF-kappaB signaling and lymphoctye activation following antigen-receptor stimulation. Mutations in this gene result in immunodeficiency 12 (IMD12). This gene has been found to be recurrently rearranged in chromosomal translocations with other genes in mucosa-associated lymphoid tissue lymphomas, including a t(11;18)(q21;q21) translocation with the baculoviral IAP repeat-containing protein 3 (also known as apoptosis inhibitor 2) locus [BIRC3(API2)-MALT1], and a t(14;18)(q32;q21) translocation with the immunoglobulin heavy chain locus (IGH-MALT1). Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, May 2018]

Versandbedingungen:: Blue Ice