DUSP4 antibody

Eine Lieferung in diese Region ist nicht möglich.

SKU:: GTX34358
Zusätzliche Namen:: DUSP4,HVH2,MKP2,TYP,dual specificity phosphatase 4
Anwendung:: WB
Konzentration:: 1 mg/ml
Physischer Zustand:: Liquid
Spezies-Reaktivität:: Human
Aufreinigung:: Affinity Purified
Lagerbedingungen:: -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
Hersteller:: Genetex
Host:: Rabbit
Reaktivitäten:: Human
Buffer:: PBS, 0.5% BSA, 50% Glycerol, 0.02% Sodium azide.
Immunogen:: Synthesized peptide derived from human MKP-2 at 50-130 aa, Internal.
Uniprot:: Q13115
Synonyme:: dual specificity protein phosphatase 4;dual specificity protein phosphatase hVH2;HVH2;MAP kinase phosphatase 2;mitogen-activated protein kinase phosphatase 2;MKP-2;MKP2;serine/threonine specific protein phosphatase;TYP;VH1 homologous phosphatase 2
Weitere Details:: The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK1, ERK2 and JNK, is expressed in a variety of tissues, and is localized in the nucleus. Two alternatively spliced transcript variants, encoding distinct isoforms, have been observed for this gene. In addition, multiple polyadenylation sites have been reported. [provided by RefSeq, Jul 2008]

Versandbedingungen:: Blue Ice