GTX34348
DCC antibody
Eine Lieferung in diese Region ist nicht möglich.
- SKU:
- GTX34348
- Zusätzliche Namen:
- CRC18,CRCR1,DCC,DCC netrin 1 receptor,IGDCC1,MRMV1,NTN1R1
- Anwendung:
- WB
- Konzentration:
- 1 mg/ml
- Physischer Zustand:
- Liquid
- Spezies-Reaktivität:
- Human
- Aufreinigung:
- Affinity Purified
- Lagerbedingungen:
- -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
- Hersteller:
- Genetex
- Host:
- Rabbit
- Reaktivitäten:
- Human
- Buffer:
- PBS, 0.5% BSA, 50% Glycerol, 0.02% Sodium azide.
- Immunogen:
- Synthesized peptide derived from human DCC at 410-490 aa, Internal.
- Uniprot:
- P43146
- Synonyme:
- colorectal cancer suppressor;CRC18;CRCR1;deleted in colorectal carcinoma;HGPPS2;IGDCC1;immunoglobulin superfamily DCC subclass member 1;MRMV1;netrin receptor DCC;NTN1R1;putative colorectal tumor suppressor;tumor suppressor protein DCC
- Weitere Details:
- This gene encodes a netrin 1 receptor. The transmembrane protein is a member of the immunoglobulin superfamily of cell adhesion molecules, and mediates axon guidance of neuronal growth cones towards sources of netrin 1 ligand. The cytoplasmic tail interacts with the tyrosine kinases Src and focal adhesion kinase (FAK, also known as PTK2) to mediate axon attraction. The protein partially localizes to lipid rafts, and induces apoptosis in the absence of ligand. The protein functions as a tumor suppressor, and is frequently mutated or downregulated in colorectal cancer and esophageal carcinoma. [provided by RefSeq, Oct 2009]
- Versandbedingungen:
- Blue Ice