GTX33977
GRID2 antibody
Eine Lieferung in diese Region ist nicht möglich.
- SKU:
- GTX33977
- Zusätzliche Namen:
- GRID2,GluD2,SCAR18,glutamate ionotropic receptor delta type subunit 2
- Anwendung:
- WB
- Konzentration:
- 1 mg/ml
- Physischer Zustand:
- Liquid
- Spezies-Reaktivität:
- Human, Mouse
- Aufreinigung:
- Affinity Purified
- Lagerbedingungen:
- -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
- Hersteller:
- Genetex
- Host:
- Rabbit
- Reaktivitäten:
- Mouse
- Buffer:
- PBS, 0.5% BSA, 50% Glycerol, 0.02% Sodium azide.
- Immunogen:
- Synthesized peptide derived from human GluR-delta2 at 800-880 aa, C-terminal.
- Uniprot:
- O43424
- Synonyme:
- GluD2;gluR delta-2 subunit;glutamate receptor delta-2 subunit;glutamate receptor ionotropic, delta-2;glutamate receptor, ionotropic, delta 2;SCAR18
- Weitere Details:
- The protein encoded by this gene is a member of the family of ionotropic glutamate receptors which are the predominant excitatory neurotransmitter receptors in the mammalian brain. The encoded protein is a multi-pass membrane protein that is expressed selectively in cerebellar Purkinje cells. A point mutation in the mouse ortholog, associated with the phenotype named 'lurcher', in the heterozygous state leads to ataxia resulting from selective, cell-autonomous apoptosis of cerebellar Purkinje cells during postnatal development. Mice homozygous for this mutation die shortly after birth from massive loss of mid- and hindbrain neurons during late embryogenesis. This protein also plays a role in synapse organization between parallel fibers and Purkinje cells. Alternate splicing results in multiple transcript variants encoding distinct isoforms. Mutations in this gene cause cerebellar ataxia in humans. [provided by RefSeq, Apr 2014]
- Versandbedingungen:
- Blue Ice