GTX33324
MRP5 antibody
Eine Lieferung in diese Region ist nicht möglich.
- SKU:
- GTX33324
- Zusätzliche Namen:
- ATP binding cassette subfamily C member 5 , ABC33 , EST277145 , MOAT-C , MOATC , MRP5 , SMRP , pABC11
- Anwendung:
- WB
- Physischer Zustand:
- Liquid
- Spezies-Reaktivität:
- Human, Mouse
- Aufreinigung:
- Affinity Purified
- Lagerbedingungen:
- -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
- Hersteller:
- Genetex
- Host:
- Rabbit
- Reaktivitäten:
- Mouse, Rat
- Buffer:
- PBS, 50% Glycerol, 0.02% Sodium azide.
- Immunogen:
- Recombinant fusion protein containing a sequence corresponding to amino acids 1-179 of human ABCC5 (NP_005679.2).
- Uniprot:
- O15440
- Synonyme:
- ABC33;ATP-binding cassette sub-family C member 5;ATP-binding cassette, sub-family C (CFTR/MRP), member 5;canalicular multispecific organic anion transporter C;EST277145;MOAT-C;MOATC;MRP5;multi-specific organic anion transporter C;multidrug resistance-associated protein 5;pABC11;SMRP
- Weitere Details:
- The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions in the cellular export of its substrate, cyclic nucleotides. This export contributes to the degradation of phosphodiesterases and possibly an elimination pathway for cyclic nucleotides. Studies show that this protein provides resistance to thiopurine anticancer drugs, 6-mercatopurine and thioguanine, and the anti-HIV drug 9-(2-phosphonylmethoxyethyl)adenine. This protein may be involved in resistance to thiopurines in acute lymphoblastic leukemia and antiretroviral nucleoside analogs in HIV-infected patients. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]
- Versandbedingungen:
- Blue Ice