GTX32452
APITD1 antibody
Eine Lieferung in diese Region ist nicht möglich.
- SKU:
- GTX32452
- Zusätzliche Namen:
- centromere protein S , APITD1 , CENP-S , FAAP16 , MHF1
- Anwendung:
- WB
- Physischer Zustand:
- Liquid
- Spezies-Reaktivität:
- Human
- Aufreinigung:
- Affinity Purified
- Lagerbedingungen:
- -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
- Hersteller:
- Genetex
- Host:
- Rabbit
- Reaktivitäten:
- Human
- Buffer:
- PBS, 50% Glycerol, 0.02% Sodium azide.
- Immunogen:
- Recombinant fusion protein containing a sequence corresponding to amino acids 1-138 of human APITD1 (NP_954988.1).
- Uniprot:
- Q8N2Z9
- Synonyme:
- APITD1;APITD1-CORT;APITD1-CORT protein;APITD1-CORT readthrough;apoptosis-inducing TAF9-like domain-containing protein 1;apoptosis-inducing, TAF9-like domain 1;CENP-S;CENPS;centromere protein S;FAAP16;FANCM associated histone fold protein 1;FANCM-associated histone fold protein 1;FANCM-interacting histone fold protein 1;Fanconi anemia-associated polypeptide of 16 kDa;MHF1
- Weitere Details:
- This gene was identified in the neuroblastoma tumor suppressor candidate region on chromosome 1p36. It contains a TFIID-31 domain, similar to that found in TATA box-binding protein-associated factor, TAF(II)31, which is required for p53-mediated transcription activation. This gene was expressed at very low levels in neuroblastoma tumors, and was shown to reduce cell growth in neuroblastoma cells, suggesting that it may have a role in a cell death pathway. The protein is a component of multiple complexes, including the Fanconi anemia (FA) core complex, the APITD1/CENPS complex, and the CENPA-CAD (nucleosome distal) complex. Known functions include an involvement with chromatin associations of the FA core complex, and a role in the stable assembly of the outer kinetochore. Alternative splicing of this gene results in multiple transcript variants. Naturally occurring read-through transcripts also exist between this gene and the downstream cortistatin (CORT) gene, as represented in GeneID:100526739. An APITD1-related pseudogene has been identified on chromosome 7. [provided by RefSeq, Nov 2010]
- Versandbedingungen:
- Blue Ice