GTX31790-PEP
NPC1 blocking peptide
Eine Lieferung in diese Region ist nicht möglich.
- SKU:
- GTX31790-PEP
- Zusätzliche Namen:
- Npc Intracellular Cholesterol Transporter 1 , Npc , Pogz , Slc65A1 , Npc1
- Anwendung:
- Neutralisation
- Konzentration:
- 200 ug/ml
- Physischer Zustand:
- Liquid
- Lagerbedingungen:
- -20[o]C Aliquot. Avoid freeze/thaw cycles.
- Hersteller:
- Genetex
- Buffer:
- PBS, 0.1% BSA, 0.02% Sodium azide.
- Immunogen:
- Niemann-Pick disease, type C1
- Spezies:
- Human
- Synonyme:
- Niemann-Pick C1 protein;NPC;NPC intracellular cholesterol transporter 1;POGZ;SLC65A1;truncated Niemann-Pick C1
- Weitere Details:
- This gene encodes a large protein that resides in the limiting membrane of endosomes and lysosomes and mediates intracellular cholesterol trafficking via binding of cholesterol to its N-terminal domain. It is predicted to have a cytoplasmic C-terminus, 13 transmembrane domains, and 3 large loops in the lumen of the endosome - the last loop being at the N-terminus. This protein transports low-density lipoproteins to late endosomal/lysosomal compartments where they are hydrolized and released as free cholesterol. Defects in this gene cause Niemann-Pick type C disease, a rare autosomal recessive neurodegenerative disorder characterized by over accumulation of cholesterol and glycosphingolipids in late endosomal/lysosomal compartments.[provided by RefSeq, Aug 2009]
- Versandbedingungen:
- Dry Ice