GTX31765
BRCC36 antibody
Eine Lieferung in diese Region ist nicht möglich.
- SKU:
- GTX31765
- Zusätzliche Namen:
- BRCA1/BRCA2-containing complex subunit 3 , BRCC36 , C6.1A , CXorf53
- Anwendung:
- ELISA, WB, IHC-P
- Konzentration:
- 1 mg/ml
- Physischer Zustand:
- Liquid
- Spezies-Reaktivität:
- Human
- Aufreinigung:
- Affinity Purified
- Lagerbedingungen:
- 2-8[o]C
- Hersteller:
- Genetex
- Host:
- Rabbit
- Reaktivitäten:
- Human, Mouse, Rat
- Buffer:
- PBS, 0.02% Sodium azide.
- Immunogen:
- BRCC36 antibody was raised against a 18 amino acid synthetic peptide from near the amino terminus of human BRCC36.The immunogen is located within amino acids 20 - 70 of BRCC36.
- Uniprot:
- P46736
- Synonyme:
- BRCA1-A complex subunit BRCC36;BRCA1/BRCA2-containing complex subunit 3;BRCA1/BRCA2-containing complex subunit 36;BRCC36;BRISC complex subunit BRCC36;C6.1A;CXorf53;lys-63-specific deubiquitinase BRCC36
- Weitere Details:
- This gene encodes a subunit of the BRCA1-BRCA2-containing complex (BRCC), which is an E3 ubiquitin ligase. This complex plays a role in the DNA damage response, where it is responsible for the stable accumulation of BRCA1 at DNA break sites. The component encoded by this gene can specifically cleave Lys 63-linked polyubiquitin chains, and it regulates the abundance of these polyubiquitin chains in chromatin. The loss of this gene results in abnormal angiogenesis and is associated with syndromic moyamoya, a cerebrovascular angiopathy. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 5. [provided by RefSeq, Jun 2011]
- Versandbedingungen:
- Blue Ice