GTX31752-PEP
Nicastrin blocking peptide
Eine Lieferung in diese Region ist nicht möglich.
- SKU:
- GTX31752-PEP
- Zusätzliche Namen:
- Nicastrin , Atag1874 , Ncstn
- Anwendung:
- Neutralisation
- Konzentration:
- 200 ug/ml
- Physischer Zustand:
- Liquid
- Lagerbedingungen:
- -20[o]C Aliquot. Avoid freeze/thaw cycles.
- Hersteller:
- Genetex
- Buffer:
- PBS, 0.1% BSA, 0.02% Sodium azide.
- Immunogen:
- nicastrin
- Spezies:
- Human
- Synonyme:
- anterior pharynx-defective 2;ATAG1874;nicastrin
- Weitere Details:
- This gene encodes a Type I transmembrane glycoprotein that is an integral component of the multimeric gamma-secretase complex. The encoded protein cleaves integral membrane proteins, including Notch receptors and beta-amyloid precursor protein, and may be a stabilizing cofactor required for gamma-secretase complex assembly. The cleavage of beta-amyloid precursor protein yields amyloid beta peptide, the main component of the neuritic plaque and the hallmark lesion in the brains of patients with Alzheimer's disease; however, the nature of the encoded protein's role in Alzheimer's disease is not known for certain. Alternatively spliced transcript variants have been described, but their full-length nature has not been determined. [provided by RefSeq, Jul 2008]
- Versandbedingungen:
- Dry Ice